The server let users to structurally annotate the mutations with using the StructMAn

Go ahead & try it out! You can easily just try out the server and explore the possibilities.

If you don't know what input is expected, you can check out the examples page. If you have any questions, check out the FAQ.

StructMan is freely available to all users without any login requirement.

StructMAn web results page is not available on mobile devices due to tables & viewers size, please visit our desktop page to check your results

• What is StructMAn

  The Structural Mutation Annotation (StructMAn) software provides annotation of non-synonymous single-nucleotide variants (nsSNVs) in the context of the structural properties of the resulting amino acid changes in the corresponding proteins. Its rationale is that if a mutation is located on an interaction interface between a protein and another protein, DNA, RNA or a small molecule, it is likely to interfere with this interaction, and mutations location in the protein core are likely to influence its stability. StructMAn was first published in Nucl Acids Res, 2016 where we showed that such structural annotation correlate well with established tools for predicting damaging effect of missense mutations. Later we have applied StructMAn to a large collection of disease-associated and neutral mutations and discovered distinct trends of their spatial distribution.

• Which input is expected?

  The StructMAn server accepts the following inputs:

  • Amino acid sequence (FASTA format)
  • (human) Ensemble transcript identifier
  • SMLF (simple mutation list format) file, you can find information here: SMLF - Structman docs
    or example SMLF file here: example SMLF file

• What is protein size limit?
  • The StructMAn server accepts maximum 10 proteins as fasta input
  • For larger proteins, you can try to install StructMAn on your local PC/server, you can find more information on our GitHub page

• Which proteins are supported?
  • The StructMAn server supports all the proteins